However, buprenorphine's mechanism of action of is quite different from the others'. Buprenorphine is a partial agonist at the mu-opioid receptors and an antagonist at the kappa receptors. 5,6 Mu-opioid receptor activity produces the analgesic effects of buprenorphine, while a strong affinity for the kappa receptors render them inactive. 6,7
Side effects requiring immediate medical attention. Along with its needed effects, buprenorphine/naloxone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking buprenorphine ...